题 目：Asymmetric Pd-NHC* Catalyzed C(sp3)-H Activation
报告人：Professor E. Peter Kundig
University of Geneva, Switzerland
地 点：费彝民楼B104会议室
时 间：2014年10月18号（星期六）下午3:00
联系人：朱成建教授 (cjzhu@nju.edu.cn), 025-83686219 E-mail：Peter.Kundig@unige.ch
Abstract：Chiral Pd-NHC* complexes catalyze the intramolecular arylation of amides to give highly enantiomerically enriched 3,3-disubstituted oxindoles. Structural studies show that conformational locking to minimize allylic strain is the key for understanding the role of the stereodirecting elements of these ligands.
The same metal ligand combination is also successful in asymmetric coupling reactions involving C(sp3)-H bonds. Highly enantioenriched indolines are accessible using either preformed- or in situ-generated catalysts. Remarkably, excellent asymmetric recognition of enantiotopic C-H bonds in unactivated methylene units has been realized. Most recent discoveries are regiodivergent reactions with cases where a enantiomers are transformed into structurally different indoline products of very high enantiomeric purity. 欢迎参加！ 有机化学学科
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