题 目：Host Molecules Based on Resorcinarenes Functionalized with Amino Acids: Their Synthesis and Use to Separate Pharmacuetical Contaminants and Uremic Toxins E-mail：roger_harrison@byu.edu Abstract：Resorcinarenes have a rich history of molecular recognition. They have cavities that can be elongated and which are known to bind guest molecules. The ability of resorcinarenes to have different functional groups makes them good candidates to be used for selective binding. In the past we have synthesized resorcinarenes with metal chelating ligands.1 We have now turned our research focus to resorcinarenes with amino acids. One of these new resorcinarenes has alanine and binds aromatic amines and separates metal ions.2,3 Our most recent resorcinarenes contain glutamic acid (Figure 1) and have shown the ability to separate and quantify pharmaceutical contaminants and uremic toxins in water. As more medications by our growing population are put into wastewater, more of these drugs are ending up in drinking water. The quantification, which relies on the separation of these contaminants of emerging concern, is facilitated by resorcinarenes when they are used as packing materials in ion chromatography. The synthesis of resorcinarenes with amino acids and their separations of water contaminants and uremic toxins will be presented. 欢迎参加！ 有机化学学科 |