题 目：Supramolecular Chemical Biology-Interfacing Supramolecular Systems with Proteins and Cells 报告人：Prof. Dr. Luc Brunsveld Eindhoven University of Technology, Netherlands 地 点：化学楼图书馆二楼报告厅 时 间：2013年3月11日（星期一）上午10:00 联系人：王乐勇教授(lywang@nju.edu.cn), 025-83592529 EDUCATION and EXPERIENCE: Email: l.brunsveld@tue.nl Homepage：http://w3.bmt.tue.nl/en/research/divisions_bme/ molecular_bioengineering_mol_imaging/chemical_biology/group_brunsveld/ 1993 � 1997：Studies of Chemical Engineering at TechnischeUniversiteit Eindhoven and Osaka University 1997 � 2001：Ph.D in supramolecular chemistry at TechnischeUniversiteitEinhoven and University of Illinois at Urbana-Champaign. (cum laude) Supervisors: Prof. Dr. E.W. Meijer / J.S. Moore 2001 � 2003： Postdoctoral fellow with Prof. Herbert Waldmann at Max-Planck Institute of Molecular Physiology 2003 � 2004： Group leader lead optimization nuclear receptors. N.V. Organon (Oss, the Netherlands) 2005 - 2008 ：Group leader at the Max-Planck-Institute for Molecular Physiology 2006 - 2009 ：Group leader at the Chemical Genomics Centre of the Max Planck Society (Dortmund) 2007: Calls to professorships in Chemical Biology from UniversiteitTwente (not accepted) and Technische Universiteit Eindhoven. 2008-: Appointment as Full Professor of Chemical Biology at the TechnischeUniversiteit Eindhoven. Prominent Awards and fellowships: 2001 Fellowship of the Alexander von Humboldt Foundation 2004 SofjaKovalevskaja Award of the Alexander von Humboldt Foundation 2006-2007 Young Leaders in Science (Ernst Schering Foundation, Berlin) 2007 Visiting Professor in Chemical Biology, University of Vigo, Spain 2008 ERC Starting Grant 2009 Griess Lectureship (RSC � East Midlands) 2009 NVBMB Award (Dutch society of biochemistry and molecular biology) 2010 Visiting Professor in Pharmacy, University of San Pablo Madrid, Spanje Abstract： Supramolecular chemistry has primarily found its inspiration in biomolecules, such as proteins, DNA, lipids, and their interactions. Currently the supramolecular assembly of designed compounds can be controlled to great extent. This provides the opportunity to combine synthetic supramolecular materials with biomolecules to modulate biological phenomena.[1] This lecture will focus on two of such concepts. Synthetic host-guest systems are applied for the controlled and reversible dimerization and immobilization of proteins. Host-guest elements are for example appended to proteins to induce or stabilize weak protein heterodimerization.[2] Other supramolecular host molecules are used to recognize specific protein elements and applied as supramolecular inducers of protein homodimerization.[3] In this way, we have generated a so-called supramolecular inducer of dimerization that can act as an allosteric modulator of protein dimerization and allows highly efficient and reversible activation of for example enzyme activity. Self-assembling supramolecular architectures provide attractive scaffolds for the organized display of biological ligands. Their dynamic nature allows for simple non-covalent synthesis of multivalent structures and for the introduction of multiple different functionalities. As an example, columnar[4] and spherical[5] supramolecular nanoparticles can be decorated with biological ligands such as sugars and peptides for the assembly of proteins along the supramolecular framework or for the recognition and entry of cells. References [1] Chem. Soc. Rev. 2010, 39, 2817-2826; Org. Biomol.Chem. 2013, 11, 219-232. [2] e.g. Angew. Chem. Int. Ed. 2007, 46 1798-1802; J. Am. Chem. Soc. 2012, 134, 19199-19206. [3] e.g. Angew. Chem. Int. Ed. 2010, 49, 895-898; Chem. Sci. 2012, 3, 2679-2684; Angew. Chem. Int. Ed. 2013, 52, in press [4] e.g. Angew. Chem. Int. Ed. 2009, 48, 2921-2924; J. Am. Chem. Soc., 2012, 134, 8086-8089. [5] J. Am. Chem. Soc. 2011, 133, 17063-17071. |