题 目：Optical switches and molecular actuators: New tools for the imaging and 报告人：Professor Gerard Marriott 时 间：2012年12月18日上午10:00 地 点：化学楼三楼报告厅 The ability to reversibly control the activity and physico-chemical properties of proteins and biomaterials in living systems would be of great utility in the engineering of complex biological systems and in nanomedicine. There are relatively few examples of small molecule actuators or fluorescent optical switches that undergo efficient and reversible, optically-driven transitions between two distinct states, and most of these are unsuitable for studies in living systems. So, the well known BIPS photochrome was utilized in living cells and animals. The incorporation of specific groups onto the aromatic backbone of the actuator can be used to manipulate metal ion concentration, specific dipolar protein interactions. Other molecular embellishments to the BIPS backbone provide opportunities for high-resolution optical control and read-out of physical properties of polymeric mimetics of the extracellular matrix. |